Temperature-sensitive and Other Mutants of the Essex 70 Strain of Newcastle Disease Virus as Vaccines
نویسندگان
چکیده
منابع مشابه
Virion functions of RNA+ temperature-sensitive mutants of Newcastle disease virus.
Virions from Newcastle disease virus mutants in four temperature-sensitive RNA+ groups were grown in embryonated hen eggs at the permissive temperature, purified, and then analyzed for biological properties at both the permissive and nonpermissive temperatures. At the permissive temperature, virions of mutants in groups B, C, and BC (11 mutants) were all lower in specific (per milligram of prot...
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Evidence is presented which confirms that temperature-sensitive (ts) mutants with an RNA- phenotype are spontaneously selected in persistent infection of cell lines with Newcastle disease virus. Persistently infected BHK-21 cells, maintained since 1973, produce no interferon and are completely susceptible to vesicular stomatitis virus. Persistent infection of a canine kidney cell line (MDCK) te...
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In order to adapt LaSota strain of Newcastle disease virus (NDV) on chick embryo fibroblast (CEF) cells, 0.1 ml from LaSota vaccine produced in Razi vaccine and serum research institute inoculated to the CEF cells and was passaged five times in the CEF grown in Eagle’s minimum essential medium (MEM). First to third passages were blind but in fourth passage cytopathic effect of virus was observe...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1977
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-34-1-47